Warren is a fiery critic of Wall Street and one of Clinton's potential vice presidential picks. Ohio has backed every successful presidential nominee since 1964 and no Republican has won the White House without carrying Ohio.
Clinton's decision to campaign with Warren for the first time in Cincinnati, a city on Ohio's southwestern border with Kentucky and Indiana, is a bid to stop Trump from gaining ground in the state by focusing on how Clinton would help improve the U.S. economy.
"Ohio reflects the broader debate that's going on about economic uncertainty and the impact of free trade in particular," said Jim Manley, a Democratic strategist supporting Clinton.
"It's very clear that Donald Trump intends to make a major play for the industrial Midwest and so I think this highlights that she doesn't intend to let him get away with it," Manley added.
Though Warren is an influential progressive within the Democratic Party, strategists said her rhetoric about breaking up too-big-to-fail banks and reining in corporate excess resonates with two groups Clinton must court to win the Nov. 8 election.
Supporters of former Clinton rival Bernie Sanders who backed the Democratic socialist U.S. senator in the primary campaign and those anxious about the economy who are drawn to Trump's promise to toss out international trade deals are both drawn to Warren's platform, strategists said.
"Warren's appeal is not limited to liberals. It extends to people like many Trump supporters who feel the system only works for the rich and powerful," Democratic strategist Brad Bannon said.
"Because of that, Cincinnati is a good place to test Warren’s appeal as a VP candidate who can attack Trump and win over some of his angry middle class supporters," he added.
Since becoming the presumptive Democratic nominee, former Secretary of State Clinton has tried to paint businessman Trump, the presumptive Republican nominee, as fundamentally unfit for the presidency.
Clinton's campaign in recent days has accused Trump of caring more about how Britain's vote to leave the European Union would benefit him financially than how it would impact the U.S. economy.
Trump's campaign said the historic vote showed Trump was in sync with a global sentiment of economic frustration and Clinton was out of step